Brief Summary of research: 

In our group we study molecules on surfaces using solid-state nuclear magnetic resonance (NMR) enhanced with dynamic nuclear polarization (DNP). The combination of DNP with NMR allows us to explore samples that have not yet been studied with NMR, including materials that are challenging for the current state of the art of NMR.

NMR is a non-destructive, atomic, site-specific technique that can give quantitative, angstrom-scale structural information in gas, liquid, and solid-phase (both crystalline and amorphous) samples. It is sensitive to the local chemical environment and to molecular motions, which makes it well suited to studying the behavior of molecules on surfaces, bulk material, and how they interact. However, in many cases the NMR sensitivity is quite low. We overcome this by increasing the NMR signal using DNP. In DNP, we irradiate with microwave irradiation on paramagnetic centers (unpaired electrons), and the interaction between the electron spins and the nuclear spins results in enhancement of the NMR signal.
 

Specific research topics related to Nanoscience and Nanotechnology: 

As part of this work, we develop DNP-NMR techniques and novel DNP enhancement agents. We are developing nano-scale materials that can be used for DNP enhancement. The materials we prepare are both inorganic, or organic polymer based, nanostructures and can contain paramagnetic centers that are either stable organic radicals or metal ions embedded into the material. We have been characterizing the materials using the Nano-Center facilities, such as SEM, TEM, Raman spectroscopy and XPS. Together with DNP-NMR, these techniques give us a better understanding of the structure of the materials, local order, porosity and more.

This work is not only important for the DNP-NMR community, but also for the nano-community. We are developing new synthesis methods for new types of materials, which may be used in a wide range of applications, such as for energy storage, for gas filtrations and more.

Brief Summary of research: 

The relationship between the 3D structure of proteins and their biological function and biochemical activity.

Specific research topics related to Nanoscience and Nanotechnology:

• Protein oligomers that form nano-structures of 5-20 nanometers
• Enzymes that form nano-fibers of proteins and/or sugar polymers
   

Brief Summary of research: 

We use intense femtosecond laser pulses to excite and probe ultrafast molecular dynamics. By combining ultrafast laser techniques with advanced fast beam imaging techniques we develop time resolved photo-fragment imaging that allows detection of molecular dissociation events on the relevant ultrafast time scales.

Specific research topics related to Nanoscience and Nanotechnology:

Size Resolved Atomic and Molecular Cluster Ions.
 

Brief Summary of research: 

Functional Nanostructures for Nanobiotechnology and Materials Science.

Specific research topics related to Nanoscience and Nanotechnology:

• DNA nanotechnology
• Nanoenzymes
• Plasmonic nanoparticles
• Semiconductor quantum dots
• Stimuli-responsive materials
• Nanocarriers for drug release
• Artificial cells

Brief Summary of research: 

Our research is focused on materials chemistry, nanomaterials and surface chemistry. We are located at the institute of chemistry at The Hebrew University of Jerusalem. The Yerushalmi group research is primarily focused on development and utilization of surface chemistry to modify the chemical and physical properties of materials at the nanoscale.

Specific research topics related to Nanoscience and Nanotechnology:

Materials, Surface Chemistry, Catalysis, Devices.

Brief Summary of research: 

We have set an multifaceted platform for the study of molecular layers-solid substrate interactions, covering Organic Chemistry, Surface Science, Molecular and Biomolecular Electronics and Photonics.

Specific research topics related to Nanoscience and Nanotechnology:

Nanolayers.

Brief Summary of research: 

Design and construction of nano-catalytic systems; polymeric and inorganic micro-and nanoreactors; sol-gel based methods for micro-and nanoencapsulations.

Specific research topics related to Nanoscience and Nanotechnology:

• Catalytic nano- and microreactors
• Magnetically separable nanocatalysts
• Catalytic periodic mesoporous organosilica (PMO) nanospheres
• Particulate ionic liquids, deep eutectic solvents and PEGs
• Smart nanosystems for the slow-release of pheromones

Brief Summary of research: 

In my research I develop mathematical and computational models to investigate tissue-level processes in health and disease.

Specific research topics related to Nanoscience and Nanotechnology:

Our focus is on understanding the principles that govern cell-cell communication in maintaining tissue homeostasis, as well as how this balance is disrupted in pathologies like fibrosis and cancer. By integrating theoretical models with experimental data, we aim to identify molecular therapeutic targets for treating these diseases. Collaborating with experimental research groups at the Hebrew University allows us to test and validate our modeling predictions for novel therapeutic strategies. Joining the nanoscience and nanotechnology community will further enhance our ability to achieve these goals

Brief Summary of research: 

Ronny Agranat's research is aimed towards the creation of generic methods, devices, and materials to be used in novel computing, communication, and sensing schemes and architectures.

Specific research topics related to Nanoscience and Nanotechnology: 

Brief Summary of research: 

Our group focuses on marine microbiology and biogeochemistry. Our mission is centered around unraveling the microscopic mechanisms microbes use to orchestrate the flux of elements within the vast oceanic expanse. We are captivated by the enigmatic ways in which microbes, the tiniest of life forms, architect and influence their microenvironments through growth and interactions while shaping our oceanic ecosystems. Employing microfluidics, microscopy, biochemistry, and computer simulations, we reveal the secrets of their adaptations and interactions and determine their impact on the environment.

Specific research topics related to Nanoscience and Nanotechnology:

Microfabrication, microfluidics, advanced microscopy and biosensors

Brief Summary of research: 

In the field of omics technology, my group use nano-LC system combined with mass spec to identify posttranslational modifications (PTMs) such as S-nitrosylation and phosphorylation in order to provide critical information on the cellular state and cell signaling. The ultimate goal is to develop nano-based drug delivery systems to treat autism spectrum disorder, Alzheimer's disease, and other neurological disorders. The Amal combines biochemical, omics, bioinformatics, pharmacological, and behavioral tools to reach their ultimate goals
Throughout my Ph.D. studies, we developed novel technology-based nano-sensors for building algorithms for disease diagnosis via exhaled breath. We designed analyzer devices from fabricated nanomaterial-based sensor arrays that were evaluated in 14 hospitals worldwide and developed analytical chemistry techniques for the detection of biomarkers for 17 different diseases

Specific research topics related to Nanoscience and Nanotechnology:

Throughout my scientific career and together with other scientists, we developed novel technology-based nano-sensors for building algorithms for disease diagnosis via exhaled breath. We designed analyzer devices from fabricated nanomaterial-based sensor arrays that were evaluated in 14 hospitals worldwide and developed analytical chemistry techniques for the detection of biomarkers for 17 different diseases. I published 12 papers in this field

In the field of proteomics, my group use nano-LC system combined with mass spec to identify posttranslational modifications (PTMs) such as S-nitrosylation and phosphorylation in order to provide critical information on the cellular state and cell signaling. Our approach will lead to the discovery of drug targets. The ultimate goal is to develop nano-based drug delivery to treat autism spectrum disorder, Alzheimer's disease, and other neurological disorders. I published 8 papers in this field

Brief Summary of research: 

Our group focuses on nanoscale thermal and magnetic imaging using scanning SQUID-on-tip microscopy. We are interested in molecular magnetism and superconductivity.

Specific research topics related to Nanoscience and Nanotechnology:

Scanning SQUID microscopy at the nanoscale.

Brief Summary of research: 

Physical mechanism controlling material behavior, specifically in driven system. I work on phase transitions, response to external load (stress and irradiaiton) and other strong drive conditions. My work includes theoretical and computaitonal modeling of response to external load as well as kinetics and thermodynamics modeling.

Specific research topics related to Nanoscience and Nanotechnology:

Nano-plasticity, mechanisms controlling response of metallic nano-structures to external drive.
 

Brief Summary of research: 

• Stochastic gene regulation under environmental noise
• Population dynamics on static and time-varying complex networks

Specific research topics related to Nanoscience and Nanotechnology:

Gene regulatory networks, Mathematical models of microbial evolution.

Brief Summary of research: 

• Laser Pattering and lithography
• Collision induced processes
• Clusters characterisation and catalysis
• Photo-catalysis of cage molecules
• Reactiviry of porous silica

Specific research topics related to Nanoscience and Nanotechnology: 

Model Heterogeneous catalysis over metallic nanoclusters, Plasmonic photocatalysis, Charged amorphous solid water nano-films as model for interstellar medium conditions.
 

Brief Summary of research: 

• Molecularly doped metals
• The Measurement of Symmetry and Chirality: Concepts and applications
• Sol-Gel Materials: Entrapment of Organic and Bioorganic Molecules
• Fractal Geometry in Chemistry and Physics
• Chemically Driven Hydrodynamic Instabilities

Specific research topics related to Nanoscience and Nanotechnology:

Nanoporosity, nanocrystals, nanohybrid materials.

Brief Summary of research: 

Brief Summary of research: 

Chemistry, physics and application of nanocrystals. A special focus is given to semiconductor nanocrystals and to hybrid metal-semiconductor nanoparticles.

Specific research topics related to Nanoscience and Nanotechnology: 

• Science and Technology of Nanocrystals: 
• Synthesis and characterization of novel nanocrystals systems
• Optical and electronic properties of nanocrystals
• Single Particle Microscopy & Spectroscopy
• Deciphering the nanocrystals surface
• Photocatalysis
• 3D and 2d printing with nanocrystals
• Doped NCs for Printed electronics
• Bio-medical application with nanocrystals

Brief Summary of research: 

Our research focuses on addressing and manipulating isolated quantum systems, with the following goals:

• Studying fundamental quantum physics and quantum information science
• Using them as building blocks for quantum computing and quantum simulation of many-body systems
• Devising novel, sensitive nanoscale sensors

Specific research topics related to Nanoscience and Nanotechnology:

Nano-sensors (nano-MRI, magnetic sensing), nano-quantum devices (quantum information processing, superconducting structures).
 

Brief Summary of research: 

Development of Liposomes based nano-drugs and lipid biophysics.

Specific research topics related to Nanoscience and Nanotechnology:

Development of liposomes based nano-drugs for the treatment of cancer, diseases that involves inflammation and auto-immune diseases, bacterial infection, osteoarthritis and toxicology of nano-particles (mainly liposomes).

Brief Summary of research: 

Flying insects can perform a wide range or aerial maneuvers better than any man-made flying device. Some insects can land upside down, change direction in a split of a second and engage prey or mates in mid-air. To achieve such impressive capabilities, insects have evolved unique flight mechanisms, including a control system that exhibits the fastest reflexes in the animal kingdom. Our goal is to understand these flight control mechanisms experimentally and eventually implement them in robotic systems. This challenge involves cutting-edge topics in control theory, fluid dynamics, physiology, neuroscience and robotics.

Specific research topics related to Nanoscience and Nanotechnology: 

3d printing.
 

Brief Summary of research: 

Quantum devices in the nanoscale for quantum information processing:

We are developing nanophotonic quantum materials that can process quantum information by scattering of light from quantum emitters:

• Nanophotonics for efficient quantum optics
• Quantum Information processing with photons
• Gravity Analogues with nonlinear optics and nanophotonics

Brief Summary of research:

Microbial ecology of extreme environments, with a focus on the microbial populations of salt-excreting plants; Microbial water quality; Genetically engineered microbial sensors for environmental monitoring, with an emphasis on toxicity and genotoxicity assessment and on the detection of specific classes of compounds, including trace pharmaceuticals and explosives.

Specific research topics related to Nanoscience and Nanotechnology:

Whole-cell biosensors.

Brief Summary of research: 

Neuro-Vascular research focused on the molecular and cellular aberrations of the Blood Brain Barrier (BBB) in central nervous system (CNS) pathologies. We also study the differentiation processes of BBB endothelial cells during embryonic development.

Specific research topics related to Nanoscience and Nanotechnology:

Brief Summary of research: 

Our research laboratory is focused on the emerging role of RNA as a target at the interface between chemical biology, medicinal chemistry, and molecular/cellular biology. We are using organic chemistry as a tool to answer fundamental questions in RNA-biology. The goal of our research is to synthesize and evaluate small molecules that bind to and alter function of specific RNA motifs in disease cellular models. These small molecules are used as probes to study and interrogate RNA complexes or as drugs to alleviate disease-associated characteristics. Importantly, our research is applicable to most of the pathologies from genetic diseases such as cancer to infectious diseases such as viral and bacterial infections.

Specific research topics related to Nanoscience and Nanotechnology:

Our lab research resides in the broad field of chemical biology. This field includes various areas of research such as organic/combinatorial chemistry, medicinal chemistry, structural biology, biochemistry, cell biology, microbiology, molecular biology… Notably, most of the research is done within the walls of our lab where biological and chemical infrastructures coexist. Our chemical biology lab is equipped with state-of-the-art equipment that contributes to the development of novel chemical approaches to drug disease-related RNA complexes.

Brief Summary of research: 

Polymeric Nanocarriers for Drug Targeting and Improved Drug Delivery.

Specific research topics related to Nanoscience and Nanotechnology:

• Enhanced percutaneous permeation of poorly permeating drugs by means of lipid and polymeric nanocarriers
• Targeted delivery of chemotherapeutic drugs to specific cancerous cells using nanoparticles conjugated to monoclonal antibodies for decreased toxicity, enhanced drug-cell penetration and performance.
• Various formulations of natural and synthetic cannabinoids  are being investigated in original self-nanoemulsifying formulations , nanoparticles , nanocapsules ,  some of them embedded in Microparticles for improved oral bioavailability of these poorly absorbed compounds.
• Oxaliplatin palmitate acetate, a novel Pt(IV) chemical entity,  derived from Oxaliplatin  is more lipophilic than OXA  and exhibits a quick clearance rate  from the blood circulation.  Its  systemic prolonged exposure  needs to be  investigated using   nano-delivery systems  to reach better efficacy and safety profile . 
• Design of Nanoemulsions and Nanoparticles for improved  ocular drug delivery.
   

Brief Summary of research: 

Developing novel therapies and drug-delivery systems based on nanotechnology and functional biomaterials.

Specific research topics related to Nanoscience and Nanotechnology: 

Nanoparticles; nanomaterials; 3D printing; responsive drug delivery; microfluidics; organ on chip; biodegradable polymer

Brief Summary of research: 

We study the structure and physical properties of new inorganic materials through synthesis and X-ray crystallography.

Specific research topics related to Nanoscience and Nanotechnology:

We specialize in developing and synthetic and crystallization techniques in aqueous solutions and investigate the properties of metal-complexes, mainly poly-nuclear and clusters in this media.

We focus on the preparation of metal complexes with biological relevance or with the potential of being used in medical imaging techniques such as CT and MRI.

We also prepare and characterize bi-metallic nano-alloys and examine their catalytic properties.

Brief Summary of research: 

We study the gut-brain axis in aging and neurological disorders. Our major research question is  how processes that occur in the gut, affect brain functions and the aging process in health and disease. To answer this question, we look at the whole-organism level to identify novel targets to treat brain pathologies. Our ultimate goal is to achieve in-depth understanding of the intestinal processes affecting brain dysfunction (mediated by immune cells, microbiomes, and metabolites) that will support the development of better treatments, prolonged lifespan and healthier aging. We carry out longitudinal pre-clinical studies in young and aged mice to elucidate systemic, long-term processes that predispose the aging organism to develop neurological damage.

Specific research topics related to Nanoscience and Nanotechnology:

At the Nano-scale – we study age-related cell-cell interactions and tissue architectural changes in brain and intestinal cells by multiplexed imaging. Using our Phenocycler Fusion system, we are able to simultaneously image 70+ markers at protein level in gut and brain sections, to discover cellular localizations, interactions and dynamics at the tissue context.

Brief Summary of research: 

Research in the Blum lab is diverse and multidisciplinary, where we use a combination of organic chemistry and biochemical methodologies. One area of our research focuses on proteases which are enzymes that cleave proteins. 

Specific research topics related to Nanoscience and Nanotechnology:

Nano imaging materials.
 

Brief Summary of research: 

Research interests include ice-binding proteins investigation with fluorescence microscopy and microfluidic devices, cryobiology, freeze casting for porous materials, and food structure.

Specific research topics related to Nanoscience and Nanotechnology:

Ice binding proteins and their interaction with ice crystals, 3D printing of food materials, Cryopreservation. 
 

Brief Summary of research: 

Brief Summary of research: 

Our group is studying how mechanobiological inputs direct cell-fate decision-making by integrating state-of-the-art single-cell genomics, microrheology, and deep learning AI. We focus on the mechanobiology of preimplantation embryo development, stem cell differentiation, inflammation, and nucleus mechanotransduction.

Specific research topics related to Nanoscience and Nanotechnology:

Mechanobiology of oocytes and embryos.

Brief Summary of research: 

"We manipulate electronic spins in atomically engineered devices to overcome the limits of conventional electronics for sensing, processing, and memory applications." 

Specific research topics related to Nanoscience and Nanotechnology:

Spintronics 

Brief Summary of research: 

Intermolecular interactions that govern extracellular biological processes. The major research topic is bacterial biofilms. 

Specific research topics related to Nanoscience and Nanotechnology:

Biomineralization, protein aggregation and network formation.

Brief Summary of research: 

Physico-chemical processes of organic pollutants occurring in water, reclaimed wastewater, soils and sediments. An overarching goal is to elucidate physical, chemical and biological processes that influence the fate of organic molecules in the environment with special emphasize on the agricultural environment.

Specific research topics related to Nanoscience and Nanotechnology:

Environmental Chemistry.

Brief Summary of research: 

• Biodegradable polymers. Design, synthesis and development of new biodegradable polymeric systems.
• Tissue engineering. Tailoring of polymers for scaffolding and regeneration of functional human tissue, especially arterial reconstruction.
• Plasma surface treatments. Surface modification of polymers by means of polymerization of functionalization under plasma conditions, for biomedical purposes.
• Biomedical injectables. Development of novel polymeric systems for in situ generated implants.
• Biomedical composites. Fiber reinforced polymers for hard and soft tissue implants and prostheses.

Brief Summary of research:

Polymers play a vital role in the world of medicine. In our lab, we focus on the development of new polymers and formulations thereof to be used in enhanced and novel therapies. Our current focus is on the development of injectable biopolymers extended delivery of anticancer and antibiotic drugs, anti-depressants, cannabinoid formulations and stability, gene delivery, tissue engineering scaffolds, antimicrobial polymers and small molecules, agriculture and cosmetic  applications of controlled release, oral delivery of insoluble drugs, novel antimicrobials, oral delivery of proteins, forensic science and much more.

Specific research topics related to Nanoscience and Nanotechnology:

• Improved bioavailability of drugs using lipid nanoparticles
• Surface crystallization of drugs
• Antimicrobial nanoparticles
• Gene delivery using cationic polysaccharide nano-complexes
   

Brief Summary of research: 

Quantum optics with multi-photon states and the precision of optical measurements.

Specific research topics related to Nanoscience and Nanotechnology:

• Quantum limited resolution of measurements
• A single photon on-demand source using a surface wave plasmonic collimator

Brief Summary of research: 

We study the nano and micro structure, and the chemical composition of plant tissues. We work mainly in two directions:

• Hygroscopic movement in seed dispersal
• The roles of silicon oxide in plant physiology.

Specific research topics related to Nanoscience and Nanotechnology:

• BIOMINERALIZATION: Production of  bio-silica by plants 
• HYGROSCOPIC MOVEMENT: Cellulose-based structure creating movement under changes of the ambient humidity

Brief Summary of research: 

Our group studies nano-scale geological processes central to hydrology and the oil and gas industry. We use a diverse array of methods, combining cutting edge lab technology, state-of-the-art modeling, and field work.

Specific research topics related to Nanoscience and Nanotechnology:

Water-rock interaction, Environmental geochemistry.
 

Brief Summary of research: 

The BioGeoChem lab studies the biogeochemical cycling of nutrients, contaminants and organic matter in soil and water systems.

Specific research topics related to Nanoscience and Nanotechnology:

We aim to decipher the mechanisms controlling the composition, structure, mobility and bioavailability of elements in natural systems, while paying special attention to nutrient and contaminant dynamics, redox status, and organic matter composition. For this purpose we use a combination of micro- and nano-scale analyses at the Nano Centre including XPS, Raman, SEM/TEM and more.

Brief Summary of research: 

The research in focuses on the development of radically new nanostructures and molecular materials for the production of innovative solar cells, third generation solar cells.

Specific research topics related to Nanoscience and Nanotechnology: 

• Thin film
• nanoparticles
   

Brief Summary of research: 

Our research is aimed at better understanding of the factors that affect drug distribution across the blood-brain barrier (BBB), introducing novel markers for studying molecular changes at the BBB itself and developing delivery systems which would be able to overcome the anatomical and functional barriers to the CNS. In particular, we focus on identification and targeting epileptogenic brain tissue. 

Specific research topics related to Nanoscience and Nanotechnology:

Improving treatment of epilepsy using nanotechnologies.

Brief Summary of research: 

The research interests of my laboratory are centred on the area of soft condensed matter physics for investigation of the structure, dynamics, and macroscopic behaviour of complex systems. (CS). CS is a very broad and general class of materials, which include associated liquids, polymers, biomolecules, colloids, porous materials and liquid crystals.

Specific research topics related to Nanoscience and Nanotechnology:

Water in Nano confinement.
 

Brief Summary of research: 

Research interests include ice-binding proteins investigation with fluorescence microscopy and microfluidic devices, cryobiology, freeze casting for porous materials, and food structure.

Specific research topics related to Nanoscience and Nanotechnology:

Ice binding proteins and their interaction with ice crystals, 3D printing of food materials, Cryopreservation. 
 

Brief Summary of research: 

Physico-chemical processes of organic pollutants occurring in water, reclaimed wastewater, soils and sediments. An overarching goal is to elucidate physical, chemical and biological processes that influence the fate of organic molecules in the environment with special emphasize on the agricultural environment.

Specific research topics related to Nanoscience and Nanotechnology:

Environmental Chemistry.

Brief Summary of research: 

We study the nano and micro structure, and the chemical composition of plant tissues. We work mainly in two directions:

• Hygroscopic movement in seed dispersal
• The roles of silicon oxide in plant physiology.

Specific research topics related to Nanoscience and Nanotechnology:

• BIOMINERALIZATION: Production of  bio-silica by plants 
• HYGROSCOPIC MOVEMENT: Cellulose-based structure creating movement under changes of the ambient humidity

Brief Summary of research: 

The BioGeoChem lab studies the biogeochemical cycling of nutrients, contaminants and organic matter in soil and water systems.

Specific research topics related to Nanoscience and Nanotechnology:

We aim to decipher the mechanisms controlling the composition, structure, mobility and bioavailability of elements in natural systems, while paying special attention to nutrient and contaminant dynamics, redox status, and organic matter composition. For this purpose we use a combination of micro- and nano-scale analyses at the Nano Centre including XPS, Raman, SEM/TEM and more.

Brief Summary of research:
Research in the Fichman lab is at the intersection of chemical biology, bionanotechnology, and materials science, focusing on functional bioinspired materials for food and healthcare applications. We exploit self-assembling systems to develop advanced biomaterials and characterize them at the nano-, micro-, and macro-scale.

Specific research topics related to Nanoscience and Nanotechnology:
Self-assembly | Peptides | Food-gels | Bacteria-material interactions | Antibacterial materials | Drug delivery

Brief Summary of research: 

Our lab investigates the response of the body to fasting. The liver is responsible for supplying the body with fuel (glucose and ketone bodies). During fasting, a set of responses are triggered within the liver in order to maintain the supply of energy to the body. This chain of reactions is made possible by thousands of genes being turned “on” and “off”.  If these reactions are not regulated, we are unable to survive fasting for more than a few hours. Conversely, if the liver produces too much fuel, this can lead to the development of diseases such as diabetes, at the root of which lies the excess unregulated production of glucose. Using genomic, metabolic and molecular biology approaches, we study the gene regulatory networks that mediate the liver’s response to fasting. We aim to better understand these networks and how their dysregulation can contribute to obesity and diabetes.

Specific research topics related to Nanoscience and Nanotechnology:

• In studying transcriptional and chromatin regulation, we focus on the interaction of transcription factors with DNA. The affinity and dynamics of TF-DNA interaction lays at the heart of gene expression regulation. These interactions occur at the nano scale and our lab has optimized methods to characterize, quantify and manipulate TF-DNA interaction in the natural setting of chromatin-wrapped DNA in living cells. 

Brief Summary of research: 

In my lab we will develop chemical tools to inhibit microbial or fungal growth in food. The interdisciplinary research program will combine food science, peptide chemistry, biochemistry and microbiology toward the design of novel antimicrobial agents for applications in food science.

Specific research topics related to Nanoscience and Nanotechnology:

Design and synthesis of copper nano-crystal for crop protection.
 

Brief Summary of research: 

The Toporik lab is focused on understating the assembly process of the photosynthetic machinery and its structural manifestation through cryo-EM.

Specific research topics related to Nanoscience and Nanotechnology:

• Structural elucidation of photosynthetic complexes and assembly factors at tenths of nanometer resolution.
• Incorporation of nano-scale protein- complexes in biotechnological applications.

Brief Summary of research: 

My scientific interests within the fields of soil chemistry and mineralogy center on colloid and interface phenomena. My approach has been to conduct basic science studies which serve as a basis for environmental application-oriented research.My expertise is modifying clay surfaces to design optimized sorbents which in turn efficiently bind pollutants. The modification is achieved by adsorbing organic molecules as monomers, micelles or polymers on the clay surface. I focus on characterizing these clay composites and studying the interactions within the composite (clay surface and modifiers) and the interactions of pollutants with these composites.

Specific research topics related to Nanoscience and Nanotechnology:

Colloid assembly, polymer-clay composites.
 

Brief Summary of research: 

I am studying the dynamics of the terrestrial carbon cycle with respect to climate change alterations. Using a set of experimental and mathematical tools, we are employing micro-scale observations using microfluidic devices to observe the complex interactions of microorganisms, water, nutrient availability, and environmental conditions in the soil matrix.

Specific research topics related to Nanoscience and Nanotechnology:

I am planning to leverage the wide range of capabilities at the Nanoscience and Nanotechnology Center to design and fabricate various experimental micro-scale equipment. This includes soil-like microfluidic chips, root systems macro-fluidic devices, and customized vessels to support my measuring equipment.

Therefore, I believe my research aligns well with the capabilities and vision of the Nanoscience and Nanotechnology Center, and I would be delighted to join as a member.

Brief Summary of research: 

We are intrigued by the sense of taste, and are aiming to understand how bitterness and sweetness are elicited and modified by molecules.

Specific research topics related to Nanoscience and Nanotechnology:

Peptides, biosensors  for taste(via collaboration).

Brief Summary of research: 

Microbial species are everywhere, and they are not alone - they reside in communities, interacting with other species, hosts and the environment. These communities are important to our health, the health of animals and plants, to the food we eat and to the environment. 

Specific research topics related to Nanoscience and Nanotechnology:

Our goal is to better understand the principles underlying microbial species assembly, function and evolution, especially under stress and perturbations. To do so, we integrate classical microbiology, high-throughput sequencing, microfluidics, microscopy and computational methods. 

Brief Summary of research: 

Our lab studies plant specialized metabolism, with a focus on elucidation of biosynthetic pathways of plant metabolites involved in defense against biotic stresses.

Specific research topics related to Nanoscience and Nanotechnology:

We are also interested in metabolic engineering of plants and microorganisms for production of molecules-of-interest.

Brief Summary of research: 

The lab studies the basic processes that control the development of the human and mammalian brain and how genetic mutations may affect these processes to lead to neurodevelopmental disorders

Specific research topics related to Nanoscience and Nanotechnology:

Therapies for neurodevelopmental disorders such as autism and early onset epilepsy have been difficult to develop due to a lack of access to human brain tissues. Stem-cell based In vitro organoids offer hope in this area, but they have limited spatial organization and cannot systematically reproduce the generation of histologically complex brain regions. By contrast, microfluidic devices allow us to generate histologically contingent, whole 3D brain organoids that developmentally and histologically mimic the formation of the human frontal neural tube. These systems hold promise for identifying specific pathophysiological pathways of brain disorders and for understanding the development of the human brain as a whole.

Brief Summary of research: 

Combining plant molecular biology, protein engineering and nano-biotechnology to develop super-performing materials for affordable and sustainable applications.

Specific research topics related to Nanoscience and Nanotechnology:

• SP1 as a nanopore for ""nanopore sequencing""
• Cellulose Nano Crystal films and coating materials
• Functional Coatings Comprised of Cellulose Nano Crystals
• Strong scaffolds for tissue engineering and regenerated medicine
• 3D printed hybrid skin implants

Brief Summary of research: 

In my research I develop mathematical and computational models to investigate tissue-level processes in health and disease.

Specific research topics related to Nanoscience and Nanotechnology:

Our focus is on understanding the principles that govern cell-cell communication in maintaining tissue homeostasis, as well as how this balance is disrupted in pathologies like fibrosis and cancer. By integrating theoretical models with experimental data, we aim to identify molecular therapeutic targets for treating these diseases. Collaborating with experimental research groups at the Hebrew University allows us to test and validate our modeling predictions for novel therapeutic strategies. Joining the nanoscience and nanotechnology community will further enhance our ability to achieve these goals

Brief Summary of research: 

Our group focuses on marine microbiology and biogeochemistry. Our mission is centered around unraveling the microscopic mechanisms microbes use to orchestrate the flux of elements within the vast oceanic expanse. We are captivated by the enigmatic ways in which microbes, the tiniest of life forms, architect and influence their microenvironments through growth and interactions while shaping our oceanic ecosystems. Employing microfluidics, microscopy, biochemistry, and computer simulations, we reveal the secrets of their adaptations and interactions and determine their impact on the environment.

Specific research topics related to Nanoscience and Nanotechnology:

Microfabrication, microfluidics, advanced microscopy and biosensors

Brief Summary of research: 

Flying insects can perform a wide range or aerial maneuvers better than any man-made flying device. Some insects can land upside down, change direction in a split of a second and engage prey or mates in mid-air. To achieve such impressive capabilities, insects have evolved unique flight mechanisms, including a control system that exhibits the fastest reflexes in the animal kingdom. Our goal is to understand these flight control mechanisms experimentally and eventually implement them in robotic systems. This challenge involves cutting-edge topics in control theory, fluid dynamics, physiology, neuroscience and robotics.

Specific research topics related to Nanoscience and Nanotechnology: 

3d printing.
 

Brief Summary of research:

Microbial ecology of extreme environments, with a focus on the microbial populations of salt-excreting plants; Microbial water quality; Genetically engineered microbial sensors for environmental monitoring, with an emphasis on toxicity and genotoxicity assessment and on the detection of specific classes of compounds, including trace pharmaceuticals and explosives.

Specific research topics related to Nanoscience and Nanotechnology:

Whole-cell biosensors.

Brief Summary of research: 

We study the gut-brain axis in aging and neurological disorders. Our major research question is  how processes that occur in the gut, affect brain functions and the aging process in health and disease. To answer this question, we look at the whole-organism level to identify novel targets to treat brain pathologies. Our ultimate goal is to achieve in-depth understanding of the intestinal processes affecting brain dysfunction (mediated by immune cells, microbiomes, and metabolites) that will support the development of better treatments, prolonged lifespan and healthier aging. We carry out longitudinal pre-clinical studies in young and aged mice to elucidate systemic, long-term processes that predispose the aging organism to develop neurological damage.

Specific research topics related to Nanoscience and Nanotechnology:

At the Nano-scale – we study age-related cell-cell interactions and tissue architectural changes in brain and intestinal cells by multiplexed imaging. Using our Phenocycler Fusion system, we are able to simultaneously image 70+ markers at protein level in gut and brain sections, to discover cellular localizations, interactions and dynamics at the tissue context.

Brief Summary of research: 

Our group is studying how mechanobiological inputs direct cell-fate decision-making by integrating state-of-the-art single-cell genomics, microrheology, and deep learning AI. We focus on the mechanobiology of preimplantation embryo development, stem cell differentiation, inflammation, and nucleus mechanotransduction.

Specific research topics related to Nanoscience and Nanotechnology:

Mechanobiology of oocytes and embryos.

Brief Summary of research: 

Structural biology of large protein complexes. Mass-spectrometry. Computational structural modeling based on multiple information sources. Protein structure prediction.

Specific research topics related to Nanoscience and Nanotechnology:

Structural characterization of macro-molecular nano-machines.
 

Brief Summary of research: 

This laboratory is dedicated to the direct measurement of these characteristics of protein systems one molecule at a time, protein-after-protein. Using these techniques we study the molecular mechanisms leading to bacterial resistance to antibiotic molecules, through structural changes in the bacterial transcription complex. Additionally, we study the mechanisms allowing  the transduction of chemical signals through proteins mechanically, and how they assist in transcriptional regulation in bacteria and in signal transduction in the eukaryotic cell.

Specific research topics related to Nanoscience and Nanotechnology:

Fabrication of micro & nano fluidic chips.
 

Brief Summary of research: 

Our lab focuses on establishing and utilizing cutting edge single cell technologies to probe chromatin and transcriptional output at the single cell level. Our lab integrates optimization of microfluidic devices, molecular and cellular biology and computational biology, to reveal how regulation at the epigenetic level is established, maintained and altered during development. Our mission is to characterize chromatin mechanisms to better understand cellular processes in helath and disease. 

Specific research topics related to Nanoscience and Nanotechnology:

Microfluidics, single cell technology development.

Brief Summary of research: 

One of the major focuses in the lab is understanding how cells maintain their “healthy” and complex protein structures during increased oxidation, which is one of the main hallmarks of aging and age-related diseases (e.g., Alzheimer, Parkinson and others). Our overarching goal is to develop a novel technology that will enable us to unravel the mystery of the cellular “redox code” and the way it defines cells and their aging process. To achieve this goal, we utilize and develop an extensive toolbox of technologies which able to quantify changes on cellular and molecular levels. For example, we have developed fluorescence-based sensors, expressed inside cells at different organelles to monitor and quantify precise changes in intracellular oxidation. This allows us to study redox-dependent heterogeneity on a single cell level as well as isolate a subset of cells with pre-defined cellular oxidation for investigation of its proteome and redox-dependent regulation. On a protein level, we have established a toolbox of cutting-edge mass spectrometry technology to map conformational changes in proteins upon interactions and/or oxidation, specifically focusing on structurally challenging proteins, such as large and dynamic protein complexes. These technologies include an automatized, high-resolution platform for conducting Hydrogen/Deuterium exchange coupled with mass spectrometry (HDX-MS), as well as in-vivo and in-vitro crosslinking (XL-MS). Currently, we are the only lab in Israel that the HDX-MS system

Brief Summary of research:

Structure and function of the nuclear pre-mRNA processing machine. Pre-mRNA splicing. Pre-mRNA processing. Regulation of gene expression in eukaryotes. Assembly and structural studies of biological systems. Autoantibodies against nuclear RNPs-probes for inflammatory myopathies and RNA processing. Physical biochemistry. Electron microscopy.

Specific research topics related to Nanoscience and Nanotechnology:

Cryo-EM of the endogenous spliceosome.
 

Brief Summary of research: 

Development of neuron-electronic hybrid systems.Neural plasticity, a multidisciplinary approach to study the mechanisms underlying short- and long-term neuronal and synaptic remodeling.The cellular, molecular and biophysical mechanisms underlying growth cone formation, navigation of neurites, target recognition, synapse formation and neuronal network construction in development, regeneration and simple forms of learning and memory processes.

Specific research topics related to Nanoscience and Nanotechnology: 

• Development and fabrication of  3D microelectrodes arrays  for simultaneous multi-site wireless intracellular recordings  of neurons from freely behaving rats.
• Development of multisite intracellular recordings and stimulation of cultured neurons, myocytes and striated muscle fibers.

Brief Summary of research: 

Hepatitis C virus (HCV) is a major health burden that infects 1-2% of the world population and leads to ~500,000 deaths and an estimated 1.5-2 million new infections annually.
Direct-acting antivirals effectively treat HCV infection, yet face major issues making the development of additional therapeutics and an effective vaccine critical to prevent HCV spread.
 
Our research objectives are:

• To study the immune recognition neutralization of HCV by the adaptive immune system.
• To explore the interactions between the HCV envelope proteins and the host cells receptors.
• Structural elucidation of the entry mechanism of HCV and HCV-related hepaciviruses.

Specific research topics related to Nanoscience and Nanotechnology:

To achieve these objectives, we utilize structural (X-ray crystallography), biochemical and functional tools. A deep understanding of the interaction between HCV and the host cells and will be use to facilitate structural-based design of novel therapeutics and subunit vaccine immunogens for better controlling of HCV spread.
 

Brief Summary of research: 

As a Systems Biology lab we combine experiments and theory to understand the design principles of biological networks.

Specific research topics related to Nanoscience and Nanotechnology:

Microfabrication of microfluidic devices.
 

Brief Summary of research: 

Our group studies nano-scale geological processes central to hydrology and the oil and gas industry. We use a diverse array of methods, combining cutting edge lab technology, state-of-the-art modeling, and field work.

Specific research topics related to Nanoscience and Nanotechnology:

Water-rock interaction, Environmental geochemistry.
 

Brief Summary of research: 

 I am fascinated by volcanoes, diamonds and pink granites*.  Perhaps this is why I am interested in the role of water and other volatiles in magmatic processes.  Volatiles are involved in most igneous processes.  They are central in formation of melts, play a major role in transporting trace elements and radio-isotopes between mantle reservoirs or between mantle and crust, and are the driving force of explosive volcanic eruptions. 

Specific research topics related to Nanoscience and Nanotechnology:

Nano-inclusions in minerals.

Brief Summary of research: 

I am marine biogeochemist and I am studying the bioavailability of iron to marine phytoplankton & the interactions between phytoplankton in the ocean and their chemical environment. In the last years we have been investigating an important colony forming marine cyanobacterium, which we discovered employ many unique pathways to capture particles and aerosols and utilize them as a nutrient source. Our studies focus on microbe-mineral interactions, trying to untangle the molecules and pathways involved in particle attachment and translocation along the colony filaments, communication and dissolution of minerals. 
With regards to the nano-center, we frequently analyze minerals and cell-mineral interactions with SEM, SEM-EDS, XRD, XRF as well as Nano-SIMS, MALDI and Synchrotron (aboard).

Specific research topics related to Nanoscience and Nanotechnology:

Desert dust is an important source of the nutrients iron (Fe), phosphorus (P), and nitrogen (N) to remote ocean regions, supporting phytoplankton growth and carbon cycling. Desertification induced by global climate change is expected to increase dust fluxes to the ocean. Elucidating the ability of phytoplankton to utilize nutrients from dust, an integrative line of research we have been advancing over the last 12 years, will assist in predicting the function of the ocean as a life-supporting system in the global change era.
Studying natural Trichodesmium colonies from the Gulf of Aqaba, we discovered unique adaptive mechanisms for capturing and storing dust particles within the colony core, enabling efficient utilization of Fe (and P) from dust. We documented a variety of biochemical pathways and physical mechanisms that assist Trichodesmium to obtain Fe from mineral sources. We showed that dust packaging in the colony core is beneficial for uptake, since cell-particle proximity minimize Fe loss by diffusion, and that natural colonies enhance dissolution rates of dust-Fe and Fe-minerals. Lately we found that Trichodesmium and its associated bacteria act together to increase availability of dust-bound iron, where bacteria secrete Fe-binding molecules that promote dust dissolution and Trichodesmium provides dust and optimal physical settings for dissolution and uptake. In addition, we revealed that Trichodesmium can sense Fe and selectively choose Fe-rich dust particles, thus optimizing Fe supply.
Over the last years we expanded our research to the nutrient P and added new disciplines and techniques such as molecular biology (identify microbial interactions and biochemical response to dust), organic chemistry (siderophore characterization), high resolution imaging (Synchrotron, MALDI, NanoSIMS) and micro-electrodes (identify chemical gradients). Trichodesmium is predicted to flourish in the warmer, acidified and “dusty” future ocean. The mechanistic understanding gained by our research on its ability to utilize dust as a nutrient source will enhance our ability to predict the ocean’s operation modes in face of global change, and hence its impact on the atmosphere and climate.
 

Brief Summary of research: 

The overarching aim of my research is to better understand the global material cycles in our planet, especially how the recycling of volatiles such as carbon and hydrogen from the surface to the deep Earth are related to the fluxes of oceanic and continental crust through time.  

Specific research topics related to Nanoscience and Nanotechnology:

I combine petrographic, geochemical and spectroscopic work utilizing various analytical capabilities (including TEM, EPMA, LA-ICP-MS, TIMS, gas mass spectrometry and Raman and infra-red spectroscopy), to study the trapped minerals and fluids in diamonds and the compositions of basaltic magmas that cover the spectrum of mantle compositional “flavors”, as monitors of deep Earth processes.