Dr. Taw​feeq Shekh-Ahmad

Taweffeq shekh-ahmad
School of Pharmacy, Institute for Drug Research

Brief Summary of research: 

we investigate the processes and sources that contribute to the generation of free radicals and reactive oxygen species that lead to oxidative stress, and its relation with pathophysiological functions in CNS disorders, mainly in epileptogenesis (the process by which brain injury leads to chronic epilepsy) and established epilepsy. We aim to develop antioxidant therapies centered around the multiple neuroprotective effects of the nuclear factor erythroid 2-related factor 2 (Nrf2), described as the "master regulator" of the anti-oxidant response. In addition, we study novel gene therapy approaches that will be implemented in different rodent models, target genes and genetic approaches, to develop antioxidant gene therapy for targeting oxidative stress in CNS diseases.